… In the fourth series of experiments, the spinal cords of mice … signaling in the spinal cord
contributed to the maintenance of … ERK1/2 and the established mechanical allodynia, our results …

… of neurons in the spinal cord leading to neuronal hyper-… contributes to the development
of VIPN and suggests that Tlr4 may be a novel target for the treatment of vincristine-induced …

… spinal cord. Intrathecally administered R-PIA also attenuated … the determination of the tumor
necrosis factor-alpha (TNF-α) … has been shown to contribute to antinociception in instances …

… ), and the upregulation of tumor necrosis factor-alpha (TNF-α)… Mechanical allodynia was
seen in VCR-treated mice on days … , causing neuroinflammation in the spinal cord. In the group …

… leads to TNF-α over expression in the spinal cord. Interestingly … the red nucleus of rats with
SNI inhibits the up-regulation of IL-… in a murine model of vincristine-induced neuropathic pain …

… not exacerbate mechanical allodynia in OHP-treated mice … coupling contributed to the onset
of mechanical allodynia and … induced an up-regulation of PK2 and PK-Rs in spinal cord and …

… oxidative stress in spinal cord tissues of mice, which were … We also found that H 2 O 2
treatment caused up-regulation of … As a type of programmed cell death, apoptosis contributes to …

… Overall, vincristine-induced gene expression changes were … mechanisms that contribute
to the development of CIPN. … spinal cord injury, burn injury, and after treatment of C57BL6 …

… Tumour necrosis factor alpha … of M1 macrophages to M2 in the spinal cord and
increase the sensitivity of … These actions of KB9 and KB10 may well contribute to their anti-nociceptive, …

… contribution of individual isoforms to VIPN is still unclear. In the present study, we established
a mouse model of vincristine-induced mechanical allodynia… is a significant up-regulation of …